A type of substituted penta- fused hexa-heterocyclic compounds havingselective inhibition for PIKfyve kinase, a pharmaceutically acceptable saltandpharmaceutically acceptable solvate thereof, a method for the preparationthereof, a pharmaceutical composition comprising the same, and use of thesecompounds in the manufacture of a medicament for preventing or treating adisease associated with PIKfyve in vivo, in particular in the manufacture of amedicament for preventing or treating tumor growth and metastasis.
