Substituted penta- and hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a preparation method therefor, a drug combination that comprises the compounds, and a usage of the compounds in the preparation of medicines that are used in the prevention or treatment of diseases associated with PIKfyve in an organism, specifically a use of the compounds in the preparation of medicines that are used in the prevention or treatment of the growth and migration of a tumor.