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Amorphous nanoparticles prepared by electrospraying
专利权人:
Nanocopoeia; LLC
发明人:
Hoerr, Robert A,Fu, Huijing,Lasch, James E.,Rahi, Mourad F.,Wertz, Christopher F.,Chen, Haigang
申请号:
AU2015353413
公开号:
AU2015353413A1
申请日:
2015.11.25
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
A method of converting a poorly water soluble crystalline compound to an amorphous compound and a method of increasing the solubility of a poorly water soluble crystalline compound in biore levant fluid at pH 6.5 is disclosed. The method includes dissolving the compound and a polymer in a solvent to form a solution, the polymer being present in the solution in an amount such that after electrospraying the solution the compound is in an amorphous form, electrospraying the solution using an electrospray system, the electrospraying forming nanoparticles, collecting the nanoparticles on a substrate, and removing the nanoparticles in the form of a powder.
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