Ronald G. Crystal,Bishnu De,Martin Hicks,Jonathan Rosenberg,Stephen M. Kaminsky
申请号：
US13635635
公开号：
US09682133B2
申请日:
2011.03.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention is directed to an adenovirus-antigen conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus, as well as a conjugate comprising (a) a disrupted adenovirus with a coat protein and (b) an antigen conjugated to the coat protein of the disrupted adenovirus. The invention also provides a method of inducing an immune response against an antigen in a human using the aforementioned conjugates. The invention further provides an adeno-associated viral vector comprising a nucleic acid sequence which encodes an antibody directed against cocaine.
