The present invention provides a MDM2 inhibitor compound, or a pharmaceutically acceptable salt thereof, which compound is useful as a therapeutic agent, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contains the MDM2 inhibitor.本發明提供一種MDM2抑制劑化合物或其醫藥上可接受之鹽,該化合物可用作尤其用於治療癌症之治療劑。本發明亦係關於含有該MDM2抑制劑之醫藥組合物。