The present invention is directed to oral care compositions comprising(i) an effective amount of a peptide or mix of peptides enriched with basicaminoacids, and (ii) a protease which cleaves said peptide and releases a basicamino acidinto an oral cavity when said composition is used in the oral cavity of auser. Saidcompositions can promote oral health and/or systemic health, includingcardiovascular health, by reducing potential for systemic infection via oraltissues.
