This Hair is bright to be related to repairing Ornaments chimeric polyeptides with improved Drug object Move Li Learn characteristic. This Hair of Ju Body Di Talk , is bright to be disclosed to improve its Drug object Move Li Learn characteristic Er as Over and repair the chimeric Flt1 Shou Body polypeptide of Ornaments. The method of It Pi Lu System Prepare and the polypeptide using the Xiu Ornaments Over, including, but unlimited what reduces using the polypeptide of Xiu Ornaments Over or inhibits lactation Move object Xue Pulp Seepage leakage and/or vasopermeability.本發明涉及具有改善的藥物動力學特性的修飾嵌合多肽。具體地講，本發明披露了爲了改善其藥物動力學特徵而作過修飾的嵌合Flt1受體多肽。還披露了製備和使用所述修飾過的多肽的方法，包括，但不限於使用修飾過的多肽降低或抑制哺乳動物的血漿滲漏和/或血管通透性。
