Formula (i) [in formula, m, n,1 R, R, R, R and R are as defined with this bill,] with the chemical compound which is shown, or the salt which that pharmacy it can allow. It discloses also the manner which uses this chemical compound for dealing with the disease which it is related to manner, and the P2X7 purine receptor which produce this chemical compound.式(I)[式中、m、n、R1、R2、R3、R4及びR5は本明細書で定義されたとおりである]で示される化合物、又はその薬学的に許容しうる塩。本化合物を製造する方法、及びP2X7プリン受容体に関連する疾患の処置のために本化合物を使用する方法も開示する。