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Antibacterial peptide
专利权人:
国立大学法人;奈良先端科学技術大学院大学
发明人:
谷原 正夫,井田 慶子
申请号:
JP2009505105
公开号:
JP5354206B2
申请日:
2008.02.25
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
Disclosed is a peptide having high safety and an excellent antibacterial activity or a salt of the peptide. Specifically disclosed is a peptide selected from the following peptides (1) and (2) or a salt of the peptide. (1) A peptide comprising an amino acid sequence represented by the general formula (I). (Pro Hyp Gly)<;SUB>;n<;/SUB>;-[(Lys x Gly)<;SUB>;m<;/SUB>;-(Pro Hyp Gly)<;SUB>;l<;/SUB>;-(Lys X Gly)<;SUB>;p<;/SUB>;]<;SUB>;a<;/SUB>;- (Pro Hyp Gly)<;SUB>;r<;/SUB>; (I) [wherein n represents an integer of 1 to 6; m represents an integer of 1 to 4; l represents an integer of 0 to 7; p represents an integer of 1 to 4; r represents an integer of 1 to 6; a represents an integer of 1 to 6; and X represents an amino acid residue selected from Ile, Leu and Hyp, provided that the (m+p) pieces of X's may be the same as or different from each other, n+m+l+p+r = 4 to 15, m+p=2 when l=0, and m=1, l=0 and p=1 when a=2.] (2) A peptide which comprises an amino acid sequence having the substitution, deletion or addition of 1 to 3 amino acid residues other than Lys, Gly and X in the amino acid sequence represented by the general formula (I), and which has an antibacterial activity.
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