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Oral therapy of vitamin B12 deficiency
专利权人:
ИНК. (US);ЭМИСФИРЕ ТЕКНОЛОДЖИС
发明人:
КАСТЕЛЛИ Кристина (US)
申请号:
RU2012136176/15
公开号:
RU2012136176A
申请日:
2011.02.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method for rapidly normalizing the vitamin B level of a vitamin B deficient patient with an average vitamin B level of less than about 350 pg / ml, comprising applying at least 15 days daily one or more oral dosage forms containing (i) N- [8- ( 2-hydroxybenzoyl) amino] caprylic acid or its pharmaceutically acceptable salt, (ii) vitamin B and optionally (iii) folic acid, according to which the daily total amount of N- [8- (2-hydroxybenzoyl) amino] caprylic acid or its pharmaceutically acceptable salt ulation from about 50 to about 250 mg and the total daily amount of vitamin Bsostavlyaet from about 0.5 to about 2 mg, at which the level of vitamin patient Bu normal within 15 dney.2. The method according to claim 1, characterized in that the average level of vitamin B of the patient is below about 200 pg / ml The method according to claim 1, characterized in that a single dosage form containing 100 mg of sodium N- [8- (2-hydroxybenzoyl) amino] caprylic acid and 1 mg of cyanocobalamin is used daily. A method of normalizing the content of the active form of vitamin Bу of a patient in need of normalization, according to which the patient has a level of active form of vitamin B below about 100 pmol / l, and which includes the daily use of one or more dosage forms containing (i) N- [8 - (2-hydroxybenzoyl) amino] caprylic acid or a pharmaceutically acceptable salt thereof, (ii) vitamin B and optionally (iii) folic acid, according to which the daily total amount of N- [8- (2-hydroxybenzoyl) amino] caprylic acid or her pharmacist a physically acceptable salt is between about 50 and about 250 mg, and daily�1. Способ быстрой нормализации уровня витамина Bу пациента с дефицитом витамина Bи средним уровнем витамина Bниже примерно 350 пг/мл, включающий ежедневное применение по меньшей мере в течение 15 дней одной или нескольких пероральных лекарственных форм, содержащих (i) N-[8-(2-гидроксибензоил)амино]каприловую кислоту или ее фармацевтически приемлемую соль, (ii) витамин Bи
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