The invention provides a method for manufacturing the compound indicated by the general formula (1) from the compound indicated by the general formula (2), and controls the amount of introduction of aryl (C1-C8) alkyl alcohol with substituents and the amount of residual carboxyl group of PASP (polyaspartic acid).The manufacturing method of the invention obtains the compound indicated by the general formula (1) by reacting the compound indicated by the general formula (2) with the aryl (C1-C8) alkyl alcohol having a substituent and the carbodiimide compound with the amount of carboxy (x and y) in the general formula (2) of more than 2 (x + y) equivalent in the solvent at 15-30 u2103 for 2-48 hours.本發明提供一種由通式(2)所表示之化合物製造通式(1)所表示之化合物之方法，且其進行可具有取代基之芳基(C1~C8)烷基醇之導入量及pAsp(聚天冬醯胺酸)之殘留羧基之量之控制。本發明之製造方法藉由使通式(2)所表示之化合物與可具有取代基之芳基(C1~C8)烷基醇、相對於通式(2)中之羧基之量(x與y之和)為2(x+y)當量以上之碳二醯亞胺系化合物於溶劑中在15~30℃下反應2~48小時，而獲得通式(1)所表示之化合物。
