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Film-coated and/or granulated calcium-containing compounds and use thereof in pharmaceutical compositions
专利权人:
NYCOMED PHARMA AS
发明人:
PIENE, JAN YNGVAR
申请号:
NZ56842906
公开号:
NZ568429A
申请日:
2006.12.07
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein is a method for the preparation of a granulated calcium-containing compound wherein the calcium-containing compound is selected from the group consisting of calcium carbonate, calcium citrate, calcium lactate, calcium phosphate including tricalcium phosphate, calcium gluconate, bisglycino calcium, calcium citrate maleate, hydroxyapatite including solvates thereof and mixtures thereof in a concentration of 50% w/w or more and in the form of particles and/or crystals, the method comprising applying a granulating composition comprising i) one or more water-soluble substances selected from the group consisting of polyols and carbohydrates, and ii) one or more polymeric substances selected from the group consisting of povidones and copovidones, and mixtures thereof, to a calcium-containing compound, and the water-soluble substance and the polymeric substance are dispersed or dissolved in a solvent. Also disclosed is a partly film-coated calcium-containing compound, wherein the calcium-containing compound is in the form of particles and/or crystals having at least part water-soluble film coating comprising i) one or more water-soluble substances selected from the group consisting of polyols and carbohydrates, and ii) one or more polymeric substances selected from the group consisting of povidones and copovidones, and mixtures thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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