Boivin, Dominique,Castaigne, Jean-Paul,Demeule, Michel,Tripathy, Sasmita,Currie, Jean-christophe,Lord-Dufour, Simon
申请号：
AU2012344702
公开号：
AU2012344702A1
申请日:
2012.11.30
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, where compound is a fusion protein including iduronate-2-sulfatase and Angiopep-2. In certain embodiments, these compounds, owning to the presence of the targeting moiety can crossing the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds.
