BOIVIN DOMINIQUE,CASTAIGNE JEAN PAUL,DEMEULE MICHEL,TRIPATHY SASMITA,CURRIE JEAN CHRISTOPHE,LORD DUFOUR SIMON
申请号：
IN4272/CHENP/2014
公开号：
IN2014CN04272A
申请日:
2014.06.09
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety for example where compound is a fusion protein including iduronate 2 sulfatase and Angiopep 2. In certain embodiments these compounds owning to the presence of the targeting moiety can crossing the blood brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features methods for treating lysosomal storage disorders (e.g. mucopolysaccharidosis Type II) using such compounds.
