The disclosure describes devices, systems, and techniques for reducing neural degeneration within a brain of a patient. In one example, a method includes delivering, via one or more ultrasound transducers, ultrasound energy focused to a targeted region of the brain of the patient according to ultrasound parameters. The ultrasound parameters are selected to generate ultrasound energy that reduces or prevents neural degeneration within at least a portion, such as a selected region, of the brain associated with the targeted region of the brain. The targeted region of the brain may include at least a portion of the selected region of the brain and/or neurons that affect different neurons within the selected region of the brain.
