(57)< Abstract > Kind or the active ingredient of two genera or more, and optionally, kind or the nutrition material of two genera or more, the solid, the liquid and/or including the forma medicine of the semi- liquid, or the aid being the constituent which becomes, the active ingredient, a) the kind which is chosen from methyl and the methylene donor or component A and b which consist of the chemical compound of two genera or more) kind or as for the constituent which consists of the component C which consists of component B, and c) kind or the bio flavonol of two genera or more which consist of the methyl carrying body of two genera or more, the transmethylation disease, desirably, gruel swelling formation Characteristic and toronbogen formation CharacteristicIt is suitable for the remedy and prevention of the heart vascular disease like the disease well.一種または二種以上の活性成分、および任意に、一種または二種以上の栄養物質、固体、液体および/または半液体の賦形剤または助剤を含んでなる組成物であって、活性成分が、a)メチルおよびメチレン供与体から選択される一種または二種以上の化合物からなる成分A、b)一種または二種以上のメチル輸送体からなる成分B、およびc)一種または二種以上のバイオフラボノイドからなる成分Cからなる組成物は、メチル基転移疾患、好ましくは、粥腫形成性およびトロンボゲン形成性疾患のような心臓血管疾患の治療および予防に良く適している。