There is an ability of this invention, (a) the medicine, the high swelling polymer and the control discharge core which includes the gas evolution medicine (while the long period of time, maintaining the physical integrity in the stomach liquid, swelling to do the said core, quickly, to achieve floating) And (b) as those inside the core the fast releasing characteristic coating composition which includes the same medicine and the shape medicine which it can allow medicine (here, the coating composition, in order for the system to offer two affinity discharges of the medicine in the stomach liquid, surrounds the core) The stomach retention control drug delivery system which is included is offered.本発明は、(a)薬物、高膨潤性ポリマーおよびガス発生剤を含む制御放出コア(該コアは、長期間、胃腸液中でその物理的完全性を維持しながら、迅速に膨潤し、浮遊を達成する能力がある);および(b)コア内のものと同じ薬物および医薬的に許容しうる賦形剤を含む速放性コーティング組成物(ここで、コーティング組成物は、システムが胃腸液中で薬物の二相性放出を提供するようにコアを取り囲む);を含む胃保持制御ドラッグデリバリーシステムを提供する。
