Katrin Hiss;Axel Dietrich;Matthias Schaefer;Thomas Huebschle;Stephanie Hachtel;Dieter Kadereit
发明人:
Dieter Kadereit,Matthias Schaefer,Stephanie Hachtel,Axel Dietrich,Thomas Huebschle,Katrin Hiss
申请号：
US13521828
公开号：
US08846690B2
申请日:
2011.01.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonistsThe present invention relates to oxazolopyrimidine compounds of the formula I,in which A, R1, R2, R3, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
