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נגזרות אציל–אמינו מצומדות המותמרות בחומצה קרבוקסילית ציקלו–פנטאן, תהליך להכנתן, תרכובות רוקחיות שלהן ושימושן להכנת תרופות
专利权人:
SANOFI
发明人:
申请号:
IL20904010
公开号:
IL209040A
申请日:
2010.10.31
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
来源网站:
中国工程科技知识中心
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