Daniel L. Flynn,Michael D. Kaufman,Bryan D. Smith,Marc Rudoltz
申请号：
US14535900
公开号：
US09457019B2
申请日:
2014.11.07
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravazation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.
