PROBLEM TO BE SOLVED: To provide a method of producing a cyclic dipeptide easily and efficiently.SOLUTION: A method of producing α cyclic dipeptide includes a step of heating an acid solution in which an amino acid or its salt is dissolved, wherein the amino acid is expressed by general formula (1). In the formula, X is an alkylene group (preferably a 2-5C alkylene group).COPYRIGHT: (C)2013,JPO&INPIT【課題】簡便かつ効率よく環状ペプチドを製造できる方法を提供すること。【解決手段】一般式(1):〔式中、Xはアルキレン基(好ましくは炭素数2~5のアルキレン基)を示す〕で表されるアミノ酸又はその塩を溶解した酸性溶液を、加熱する工程を含む、α環状ジペプチドの製造方法。【選択図】なし