WOO, YOUNG EUN,禹姈银,禹姈銀,JANG, MYUNG HYUN,张明贤,張明賢,PARK, YOUNG JIN,朴永振,PARK, YOUNG KYUNG,朴荣敬,朴榮敬,LIM, CHANG KI,林昌基,KWON, SE CHANG,权世昌,權世昌
申请号：
TW101119709
公开号：
TWI560198B
申请日:
2012.06.01
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.本發明係有關包含長效胰島素接合物與長效促胰島素肽接合物之用以預防或治療糖尿病之組成物，以及有關治療糖尿病之方法，更特定言之，共同投予該長效胰島素接合物與該長效促胰島素肽接合物係抑制由胰島素治療所引起之體重增加，及由促胰島素肽治療所引起之嘔吐及噁心，並且降低所需之胰島素劑量，藉以顯著改善服藥順從性。此外，本發明長效胰島素接合物與長效促胰島素肽接合物係分別由胰島素或促胰島素肽利用非肽基連接體而連接免疫球蛋白Fc區所製成，藉以展現改善之活體內之持續效力及安定性。
