Woo, Young Eun,Jang, Myung Hyun,Park, Young Jin,Park, Young Kyung,Lim, Chang Ki,Kwon, Se Chang
申请号：
AU2012263098
公开号：
AU2012263098A1
申请日:
2012.06.01
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved
