Ana C. Pastini,Joaquina Faour,Juan A. Vergez,Marcelo A. Ricci,Gustavo A. Fischbein
申请号：
US12146069
公开号：
US08637080B2
申请日:
2008.06.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides a simple and improved rupturing controlled release device that is capable of providing a controlled release of active agent contained in the core first through a preformed passageway and then through an in situ formed second passageway into an environment of use in a standardized release profile manner. The rupturing controlled release device comprises a core comprising at least one drug and at least one osmopolymer, a semipermeable membrane enclosing the core and having at least one preformed passageway there through, wherein the semipermeable membrane ruptures during use to form a second passageway in the semipermeable membrane at a location spaced away from the preformed passageway, and a release-controlling subcoat between the core and the semipermeable membrane.
