A closure system is provided that may include a plurality of needle carriers each having detachable needles and at least one of the detachable needles detachably coupled to the needle carriers. The detachable needle may be configured to resist proximal movement when deployed in a vessel wall. The closure system may further include at least one suture secured to each of the detachable needles and a guide member having a plurality of first lumens in which each of the first lumens is sized to receive one of the needle carriers and one of the detachable needles coupled to the needle carrier. The first lumens may direct the needle carrier and the detachable needle radially outward and distally away from the guide member.
