LAWRENCE A. BLACK,KARLA DRESCHER,MICHAEL OCHSE,BERTHOLD BEHL,CLARISSA JAKOB,LOIC LAPLANCHE,JÜRGEN DINGES,KATJA JANTOS,SEAN TURNER,HERVÉ GENESTE
申请号：
DO2014000097
公开号：
DOP2014000097A
申请日:
2014.05.08
申请国别(地区):
DO
年份:
2014
代理人:
摘要：
The new formula one compound, an inhibitor of a 10A phosphate, is used to make drugs. These compounds are suitable for the treatment or control of selected medical disorders from neurological disorders to mental disorders, the improvement of symptoms related to neurological disorders, and the reduction of the risk of their development. In formula I, q is o or s； X1 is n or CH； X2 is n or c-r7； X3 is O； s-x4 = C (R8)--Where C (R8) is combined with carbon atom, R2, or X5 = C (R9) -,where X5 is attached to the carbon atom that binds to R2； X4 is N or C-R9； X5 is N； Het is selected from an optionally substituted phenyl, a monocyclic hetaryl or a fused bicyclic hetaryl； R1 is selected among others, from hydrogen, a halogen, OH, a C1-C4-alkyl, a trimethylsilyl, a C1-C4-alkylsulfanyl, a C1-C4-alkoxy-C1-C4-alkyl, a C1-C4- alkoxy, a C1-C4-alkoxy-C1-C4-alkoxy or the Y1-Cic1 unit； R2 is selected from hydrogen, a halogen, OH, a C1-C4-alkyl, a trimethylsilyl radical, a C1-C4-alkylsulfanyl, a C1-C4-alkoxy-C1-C4-alkyl, a C1-C4-alkoxy, a C1-C4-alkoxy-C1-C4-alkoxy or a C2-C4-alkenyloxy, among others；A represents one of the following categories A1, A2, A3, A4 or A5:*In each case, it represents the junction of the Hutt and the nitrogen atom, where R3, R9, R3E, r3f, a ',Y1 and cic1 are defined in the claim.Nuevos compuestos de fórmula I, que son inhibidores de la fosfodiesterasa del tipo 10A. Su uso en la manufactura de un medicamento. Dichos compuestos son apropiados para tratar o controlar trastornos médicos que se seleccionan entre los trastornos neurológicos y los trastornos psiquiátricos, para mejorar los síntomas asociados a dichos trastornos y para reducir el riesgo de que se desarrollen. En la fórmula I, Q es O o S； X1 es N o CH； X2 es N o C-R7； X3 es O； S -X4=C(R8)-, donde C(R8) está unido al átomo de carbono que comprende el radical R2, o X5=C(R9)-, donde X5 está unido al átomo de carbono que se une a R2； X4 es N o C-R9； X5 es N； Het se selecciona entre un fenilo opcionalment
