The present invention is based on an efficient natural compounds chitin and tinosporin for the treatment of HIV, HTLV thereof. The invention emphasize specially on the application of compounds chitin and tinosporin which is acts as an immunomodulator. It increases innate immunity of the host where as tinisporin selectively inhibit virus from establishing infection to target t helper cells. The exact mechanism by which it prevent infection of virus and host cell is not known but on analysing from cell culture incubated with virus doesnt show any series activation of host cell it suggest either virus is not entering in to the cell or,after entry it could not get activated. The concentration of tinosporin for prevention is 10% isolated in to active form from its natural source. The concentration of chitin >20 um size for prevention is 10% solution base also plant lectins are added to boost up the effect. The remedy is effective against all type of retroviruses and other viruses which enters in to the cell via receptor binding and then cell entry mechanism. Another advantage of this drug is that it is very cost effective and not toxic because all the substance is of natural origin as comparative to existing drug which is toxic and expensive and not 100% effective too. The unique feature of invention is that it is the first natural fusion inhibitor for HIV or retroviruses and thus these compounds have no side effect. WO2011135578A1