Amino acid derivates functionalized on the n-terminal capable of forming drug incapsulating microspheres

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专利权人:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人:

Dong, Yizhou,Love, Kevin,Langer, Robert,Anderson, Daniel,Chen, Delai,Chen, Yi,Vegas, Arturo,Alabi, Akinleye,Zhang, Yunlong

申请号：

NZ73361012

公开号：

NZ733610A

申请日:

2012.10.26

申请国别(地区):

NZ

年份:

2019

代理人:

摘要：

Described herein are compounds and compositions that are characterized by the Markush formulae (I), (II), (III), (IV), (V), and (VI) underneath, where at least one terminal amino group is further functionalized. Such compounds are obtained by reacting a terminal or internal amino group with epoxides, acrylates, or aldehydes bearing lipophilic groups. The resulting amino acid, peptide, polypeptide-lipids (named “APPLs” in the application) are deemed useful as drug delivery systems including nucleotide delivery to cells.

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