PROBLEM TO BE SOLVED: To provide novel salt of S-adenosylmethionine (SAMe) having improved stability and comprising SAMe of at least 70 wt.%.SOLUTION: This invention provides salt of SAMe represented by the following formula. The salt is useful for treatment of depression. In the formula, HX is strong mineral acid having acid dissociation constant (pKa) of less than 2.5 such as hydrochloric acid, sulfuric acid, phosphoric acid； n and m are the number of 0.5-2.0； and Y is one or more selected from calcium oxide, magnesium oxide, calcium chloride, magnesium chloride, calcium sulfate and magnesium sulfate.【課題】改善された安定性を有し、少なくとも７０重量％のＳＡＭｅを含有するＳ－アデノシルメチオニン（ＳＡＭｅ）の新規の塩の提供【解決手段】下記式で表されるＳＡＭｅの塩。前記塩は、うつ状態の治療に有用である。［ＨＸは塩酸、硫酸、リン酸等の２．５未満の酸解離定数（ｐＫａ）を有する強鉱酸；ｎ及びｍは０．５～２．０の数；Ｙは酸化カルシウム、酸化マグネシウム、塩化カルシウム、塩化マグネシウム、硫酸カルシウム及び硫酸マグネシウムから選択される１以上］【選択図】なし
