Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.or a pharmaceutically acceptable derivative thereof,where:M is CO, SO or SO2；R1sand R2s are selected as follows:(i) R1s is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyI； and R2s is selected from hydrogen, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, OR11 and NR15R16, or(ii) R 1sand R2s together with the nitrogen atom on which they are substituted form a heterocyclic or heteroaryl ring；R3s, R4s and R5s are each independently selected from (i) or (ii) as follows:(i) R3s is hydrogen or alkyl； R4s is alkyl； and R5s is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroarylium, cycloalkyl, heterocyclyl and NR15R16；(ii )R5s and R3s or R5s and R4s together with the atoms on which they are substituted form heterocyclic or heteroaryl ring and the other of R3s or R4s is selected as (ii)；R6s is hydrogen, lower alkyl, lower alkenyl or lower alkynyl；R7s is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyl.The other variables are as defined in the claims.
