The present invention relates to compositions, including pharmaceutical compositions for oral administration, comprising: at least one therapeutically active agent at least one surface active agent at least one ester of poly-carboxylic acid and/or at least one ester of an aromatic carboxylic acid and a non-aqueous medium, for use in the gastric absorption of said at least one therapeutically active agent of the composition and methods of oral administration of at least one therapeutically active agent utilizing compositions of the invention.