CATRON NATHANIEL D.,TAO ZHI-FU,WANG XILU,SOUERS ANDREW J.,SULLIVAN GERARD
申请号：
NZ60328411
公开号：
NZ603284A
申请日:
2011.05.25
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed herein is a compound of formula (I), (II) or (III), wherein the variables are defined herein, and the use in the treatment of bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, lymphoidmalignancies of T -cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, chronic lymphocytic leukemia, myeloma, prostate cancer, small cell lung cancer or spleen cancer Embodiments of the compound include the following: (5-{ 5-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-[({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)carbamoyl] phenoxy} -7H-pyrrolo[2,3-b]pyridin-7-yl)methyldihydrogen phosphate； and trans-4-[(4-{ [4-(4-{ [2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl} piperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl} -2-nitrophenoxy)methyl]cyclohexyldihydrogen phosphate
