pharmaceutical composition, crystalline form of the bendamustine free base and method of treatment of chronic lymphocytic leukemia, hodgkin's disease, non-hodgkin's lymphoma, multiple myeloma or breast cancer
CURTIS R. HALTIWANGER,LAURENT D. COURVOISIER,MARK EDDLESTON,ROBERT E. MCKEAN
申请号:
BRPI1004922
公开号:
BRPI1004922A2
申请日:
2010.01.14
申请国别(地区):
BR
年份:
2019
代理人:
摘要:
Novel polymorphic forms of bendamustine free base are described, including amorphous bendamustine free base, six anhydrous crystalline forms, four hydrate forms, and five solvate forms, with methods of their preparation and use also being described.