The present invention relates to a system for delivering, distributing and retaining a liquid, a gel or a cream substance into a vaginal or an anal cavity of a human or animal, comprising an applicator (30) and a flexible web (1) wherein a first portion (1') of the web (1) is folded over a remaining second portion (1") of the web (1) along a folding line (L) and the first (1') and second (1") portions of the web (1) are maintained in a folded position by a plurality of welding regions (23), thereby defining a retaining pouch (2) having lateral edges corresponding to said welding regions (23) and a top opening and a bottom opening (O) for receiving the applicator (30), wherein the top is the side of the pouch closest to the folding line and the bottom is the side of the pouch furthest away from the folding line (L) and a zone (Z) which is delimited by the folding line (L) and by said top opening of the pouch and on the lateral sides by two further openings (O1, O2), situated at the extremities of the folding line (L), wherein the top opening is delimited by two extremities of the welding regions (23) and is configured to receive said applicator (30) and to keep said applicator (30) in a releasably fixed position when its end comprising the at least one orifice is in the zone (Z), in order to deliver the substance into the cavity.
