The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula Iin which Z is an oxygen atom, two hydrogen atoms, a group =NOR or =NNHSO2R, where R is a hydrogen atom or a straight-or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6and/or R7may have α or β configuration, and R6and R7are independently of one another a hydrogen atom or a straight- or branched- chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond.The novel compounds have progestational and antimineralocorticoid activity.本發明描述通式I之新穎18－甲基－19－去甲雄甾－4－烯17,17－螺醚：其中：Z為氧原子、兩個氫原子、基團＝NOR或＝NNHSO2R，其中R為氫原子或具有1至4個或3至4個碳原子之直鏈或支鏈烷基；R4為氫原子、鹵素原子或三氟甲基；且R6及/或R7可具有α或β構型，且R6及R7彼此獨立地為氫原子，或具有1至4個或3至4個碳原子之直鏈或支鏈烷基，或具有2至4個或3至4個碳原子之直鏈或支鏈烯基，或具有3至5個碳原子之飽和環烷基，或一起為亞甲基或雙鍵。該等新穎化合物具有助孕及抗鹽皮質激素活性。
