KA, SHUK MAN,贾淑敏,賈淑敏,HUA, KUO FENG,花国锋,花國鋒,CHEN, ANN,陈安,陳安
申请号：
TW102123329
公开号：
TW201500040A
申请日:
2013.06.28
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention relates to use of creosol i.e. 2-methoxy-4-methylphenol or a pharmaceutically acceptable salt or a physiologically functional derivative thereof for treating inflammatory disorder particularly the compound is effective to inhibit NO or IL-6 expression, caspase-1 activation or IL-1βsecretion, and NLRP3 and IL-1β precursor expression in inflammatory cells of the subject.本發明係有關木焦油醇亦即2-甲氧基-4-甲基酚或醫藥上可接受之鹽或生理功能衍生物用於治療發炎疾病的用途;特別是該化合物係有效抑制個體發炎細胞中NO或IL-6表現、凋亡蛋白酶-1活化或IL-1β分泌及NLRP3和IL-1β前驅物表現。
