A novel compound according to Formula I, able to inhibit JAK as disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons.本發明揭示能夠抑制JAK之新穎式I化合物,此化合物可製成醫藥組合物,且可用於預防及治療哺乳動物(包括人類)之多種病況,其非限制性實例包括過敏或發炎性病況、自體免疫疾病、增殖性疾病、移植排斥、涉及軟骨更新損傷之疾病、先天性軟骨畸形及/或與IL6或干擾素分泌過多相關之疾病。
