The present invention discloses compounds according to Formula I:wherein R1, R2a, X, Y, and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of IL-6, diseases associated with hypersecretion of TNFα, interferons, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.本發明揭示式I化合物：其中R1、R2a、X、Y及Z如本文所定義。本發明係關於化合物、其製備方法、包含其等之醫藥組合物及藉由投與本發明化合物來預防及/或治療以下疾病的治療方法：發炎性疾病，自體發炎性疾病，自體免疫性疾病，增生性疾病，纖維化疾病，移植排斥，涉及軟骨轉換障礙之疾病，先天性軟骨畸形，涉及骨骼轉換障礙之疾病，與IL-6分泌過多相關之疾病，與TNFα、干擾素、IL-12及/或IL-23分泌過多相關之疾病，呼吸道疾病，內分泌及/或代謝疾病，心血管疾病，皮膚病，及/或異常血管生成相關疾病。
