Cyriaque Beley;Lina Li;Thomas Voit;Luis Garcia;Robert Michael Kotin
发明人:
Luis Garcia,Cyriaque Beley,Thomas Voit,Robert Michael Kotin,Lina Li
申请号：
US14004379
公开号：
US09598703B2
申请日:
2012.03.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.
