DIKOVSKIY ALEKSANDER, VLADIMIROVICH,DOROZHKO OLEG, VALENTINOVICH,Диковский, Александр Владимирович,Дорожко, Олег Валентинович
申请号：
EA201100857
公开号：
EA022204B1
申请日:
2010.04.23
申请国别(地区):
EA
年份:
2015
代理人:
摘要：
The invention relates to medicine and pharmacology, in particular, to preparations for the treatment of gastric and duodenal ulcer. A pharmaceutical composition contains at least one proton pump inhibitor (PPI) and at least one prebiotic from the group of aliphatic alcohols, or disaccharides, or polysaccharides, or fructooligosaccharides, or galactooligosaccharides. The content of the composition components in wt.%: proton pump inhibitor - 0.05-25； prebiotic from the group of aliphatic alcohols, or disaccharides, or polysaccharides, or fructooligosaccharides, or galactooligosaccharides - 40-95； excipients - up to 100. The composition allows effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum antibiotics, as well as the comprehensive treatment of ulcer disease associated with a helicobaterial infection. The claimed pharmaceutical composition makes it possible, in conditions of an elevated pH of the stomach contents, to actively stimulate the growth of lactobacilli in the upper sections of the gastrointestinal tract, including the duodenum, and substantially increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment. Also proposed is a method for the treatment of gastric and duodenal ulcer, whereby the eradication of H. pylori is attained during the course of therapy providing enteral administration of the pharmaceutical composition of PPI and prebiotic.Изобретение относится к медицине и фармакологии, а именно к лекарственным средствам - для лечения язвенной болезни желудка и двенадцатиперстной кишки. Фармацевтическая композиция состоит по меньшей мере из одного ингибитора протонной помпы (ИПП) и по меньшей мере одного пребиотика из группы алифатических спиртов, или дисахаридов, или полисахаридов, или фруктоолигосахаридов, или галактоолигосахаридов. Содержание компонентов композиции в мас.% составляет ингиби
