method for treating a tumor, method for identifying a subject, method for selecting a treatment, and kit

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专利权人:

VARIAN MEDICAL SYSTEMS; INC.

发明人:

Renate Parry

申请号：

BR112015023493

公开号：

BR112015023493A2

申请日:

2014.03.14

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “method for treating a tumor, method for identifying a subject, method for selecting a treatment, and kit” the methods described in this document allow classification Patients in groups to receive optimized radiation treatment based on patient-specific biomarker signature. The biomarker signature includes markers that have been shown to correlate with tgf-î² expression and to be associated with tumor aggressiveness, radiation resistance, and poor prognosis. Markers play a key role in the epithelial mesenchymal transition. The methods described in this document provide the dual benefits of anti-tumor efficacy plus normal tissue protection by combining tgf-γ² inhibitors with ionizing radiation to treat cancer patients.1 / 1 resumo “mã‰todo para tratamento de um tumor, mã‰todo para identificar um sujeito, mã‰todo para a seleã‡ãƒo de um tratamento, e, kitâ€� os mã©todos descritos neste documento permitem a classificaã§ã£o de pacientes em grupos para receber tratamento de radiaã§ã£o otimizado baseado em assinatura de biomarcador especã­fica do paciente. a assinatura de biomarcador inclui marcadores que mostraram se correlacionar com a expressã£o de tgf-î² e serem associados com agressividade do tumor, resistãªncia a radiaã§ã£o e prognã³stico pobre. os marcadores desempenham um papel chave na transiã§ã£o mesenquimal epitelial. os mã©todos descritos neste documento proveem os benefã­cios duplos de eficã¡cia antitumoral mais proteã§ã£o de tecido normal ao combinar inibidores tgf-î² com radiaã§ã£o ionizante para tratar pacientes com cã¢ncer.

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中国工程科技知识中心

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http://www.ckcest.cn/home/