AKERMAN, EUGENA A.,CLEEREN, DIRK,LLANOS, GERARD,MARYANOFF, CYNTHIA A.,PAPANDREOU, GEORGIOS,RION, WILLIAM L.,SIX, KAREL,TODD, THOMAS L.
申请号:
CA2575309
公开号:
CA2575309C
申请日:
2005.07.26
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
Processes for coating implantable medical devices that improve the stabilityof therapeutic agents contained within the coating. In one embodiment, theprocess comprises: applying a primer coating on the implantable medicaldevice; preparing a basecoat solution comprising polymers and a therapeuticagent and applying the basecoat solution to the implantable medical devices;preparing a topcoat solution comprising at least one polymer and applying thetopcoat solution to the implantable medical devices coated with the basecoatsolution; applying a solvent to partially redissolve the topcoat and basecoatwhile altering the surface finish and dissolution properties of thetherapeutic agent; and final processing the implantable medical devices,including inspecting, packaging and sterilizing the coated medical devices.