AKERMAN, EUGENA A.,CLEEREN, DIRK,LLANOS, GERARD,MARYANOFF, CYNTHIA A.,PAPANDREOU, GEORGIOS,RION, WILLIAM L.,SIX, KAREL,TODD, THOMAS L.
申请号：
CA2575309
公开号：
CA2575309C
申请日:
2005.07.26
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Processes for coating implantable medical devices that improve the stabilityof therapeutic agents contained within the coating. In one embodiment, theprocess comprises: applying a primer coating on the implantable medicaldevice； preparing a basecoat solution comprising polymers and a therapeuticagent and applying the basecoat solution to the implantable medical devices；preparing a topcoat solution comprising at least one polymer and applying thetopcoat solution to the implantable medical devices coated with the basecoatsolution； applying a solvent to partially redissolve the topcoat and basecoatwhile altering the surface finish and dissolution properties of thetherapeutic agent； and final processing the implantable medical devices,including inspecting, packaging and sterilizing the coated medical devices.
