A stabilized 1,25 -dihydroxy vitamin D2 composition, free of methyl formate, which is particularly well suited for pharmaceutical formulations, pharmaceutical formulations of the 1,25 -dihydroxyvitamin D2 composition, and a method of making the purified composition by purifying a crude 1,25 -dihydroxy vitamin D2 from acetone/water, are disclosed. The stabilized 1,25 -dihydroxy vitamin D2 is characterized by a reduced rate of degradation on heat challenge and during prolonged storage and exhibits excellent storage stability when formulated in a pharmaceutical dosage form, e.g., a soft gelatin capsule.
