CHRISTIAN ROHLFF,クフリストイアン ロフルフフ,JONATHAN ALEXANDER TERRETT,ジョナトハン アレクアンデル テルレトト
申请号：
JP2015215376
公开号：
JP2016047835A
申请日:
2015.11.02
申请国别(地区):
JP
年份:
2016
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide antibodies against Cadherin-17, nucleic acids encoding the antibodies and therapeutic proteins, methods for preparing the anti-Cadherin-17 antibodies and methods for treating Cadherin-17 mediated diseases such as human cancer including colorectal cancer.SOLUTION: The invention provides isolated antibodies, including monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors including the nucleic acid, host cells including the nucleic acid and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.SELECTED DRAWING: Figure 35A-B【課題】カドヘリン-17に対する抗体、前記抗体及び治療用タンパク質をコードする核酸、前記抗カドヘリン-17抗体を調製する方法、及び、カドヘリン-17媒介性疾患（例えば、結腸直腸癌を含むヒトの癌）等の疾患の治療方法の提供。【解決手段】カドヘリン-17に高親和性で特異的に結合するモノクローナル抗体を含む単離された抗体、前記をコードする核酸分子、前記核酸分子を含む発現ベクター、前記核酸分子を含む宿主細胞、及び、前記抗カドヘリン-17抗体を発現させる方法。さらに、抗カドヘリン-17抗体を含む二重特異性分子及び医薬組成物、前記抗カドヘリン-17抗体を用いたカドヘリン-17を検出する方法、及び、結腸直腸癌を含む種々の癌を治療する方法。【選択図】図３５Ａ－Ｂ
