The present invention relates to a pharmaceutical composition containing 2-deoxidized glucose as an active component for preventing and treating arthritis and, more specifically, to a pharmaceutical composition which controls expressions of COX-2 and PGE2 to be effective in the inflammation. The pharmaceutical composition of the present invention provides a pharmaceutical composition for preventing and treating arthritis which has less side effects than conventional synthetic drugs and has an excellent effect of relieving the symptoms of arthritis.본 발명은 2-탈산포도당을 유효성분으로 함유하는 관절염 예방 및 치료용 약학적 조성물에 관한 것으로, 상사하게는 상기 약학적 조성물은 COX-2 및 PGE2 발현을 억제하여 염증에 효과적일 수 있다.