The present invention relates to a pharmaceutical combination comprising a glucokinase initiator or a pharmaceutically acceptable salt thereof, an isotopic label thereof, a crystalline form thereof, a hydrate, a solvate, a diastereomer or an enantiomer Body form and biguanide hypoglycemic drugs. The invention further relates to a pharmaceutical composition, a fixed-dose compound preparation, a method for preparing the pharmaceutical composition and the fixed-dose compound preparation, and uses thereof.本發明涉及一種藥物組合，所述藥物組合包含葡萄糖激酶啟動劑或其可藥用鹽、其同位素標記物、其結晶形式、水合物、溶劑合物、非對映異構體或對映異構體形式和雙胍類降糖藥物。本發明進一步涉及一種藥物組合物、一種固定劑量複方製劑，以及所述藥物組合物和所述固定劑量複方製劑的製備方法及其用途。
