PROBLEM TO BE SOLVED: To provide an immunoadjuvant that excels in biocompatibility, and can efficiently exert a strong immunostimulating activity, and that can be used to a cancer immunotherapy including a treatment of cancer or the like.SOLUTION: The immunostimulating agent support fine particle is such that tuberculin, purified tuberculin, BCG bacterium formulation, a human type Mycobacterium bovis hot-water extract, granulocyte, a macrophage colony stimulating factor or interleukin 2 is supported with calcium phosphate to the surface of fine particles including mesoporous silica, zinc-containing tricalcium phosphate of 0.5-7 mol% of a zinc content or magnesium-containing tricalcium phosphate of 0.5-7 mol% of a magnesium content as an immunostimulating agent.COPYRIGHT: (C)2013,JPO&INPIT【課題】生体適合性に優れ、かつ強い免疫刺激活性を効率的に発揮することができ、癌の治療などを含む癌免疫療法に利用可能な免疫アジュバントを提供する。【解決手段】メソポーラスシリカ、亜鉛含有量0.5~7 mol%の亜鉛含有リン酸三カルシウム、又はマグネシウム含有量0.5~7 mol%のマグネシウム含有リン酸三カルシウムを含む微粒子の表面に免疫刺激因子としてツベルクリン、精製ツベルクリン、BCG菌製剤、ヒト型結核菌熱水抽出物、顆粒球・マクロファージコロニー刺激因子、又はインターロイキン-2をリン酸カルシウムと共に担持させた免疫刺激因子担持微粒子。【選択図】なし
