An object of the present invention is to provide a preparation that can suppress the generation of main degradation products of ED-71, tachysterol and trans forms of ED-71, generated under storage at room temperature. The present invention provides a preparation comprising (5Z,7E)-(1R,2R,3R)-2-(3-hydroxypropoxy)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol, fat and oil, and an antioxidant.