THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
BOXER, MATTHEW BRIAN,ROHDE, JASON MATTHEW,PRAGANI, RAJAN,LIU, LI,DAVIS, MINDY IRENE EMILY,BRIMACOMBE, KYLE RYAN,SHEN, MIN,SIMEONOV, ANTON,KARAVADHI, SURENDRA,URBAN, DANIEL JASON,JADHAV, AJIT,WANG, XIA
申请号：
CA2971872
公开号：
CA2971872A1
申请日:
2015.12.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.
