PROBLEM TO BE SOLVED: To provide a glycolipid derivative with an &alpha-C-glycoside bond, having a powerful antitumor activity and immunostimulation action, stable to glucosidase metabolism, acids and bases, and stored for a long time at room temperature.SOLUTION: There is provided the compound represented by general formula (I) or its pharmaceutically permissible salts, [wherein W is a 9-17C saturated or unsaturated hydrocarbon chain and further contains a hydroxy group in some cases, X is an 11-25C saturated or unsaturated hydrocarbon chain and further contains a hydroxy group in some cases. Y represents -(CH2)a-CH=CH-(CH2)a- or -(CH2)a- (in the proviso that a, a are each an integer of 0-5, and a+a&le5), Z represents -CO- or -SO2-, R represents a -CH2OH, -CO2H, -CH2OCH2CO2H, or -CH2OSO3H group, and R0 represents a -OH, -NH2, or -NHAc group].COPYRIGHT: (C)2010,JPO&INPIT【課題】強力な抗腫瘍活性や免疫賦活作用を有し、グルコシダーゼ代謝、酸・塩基に安定で、且つ室温で長期保存できるα-C-グルコシド結合を有する糖脂質誘導体の提供。【解決手段】次式の一般式(I):[式中、Wは炭素数9~17の飽和又は不飽和炭化水素鎖であり、更に水酸基を含む場合もある。Xは炭素数11~25の飽和又は不飽和炭化水素鎖であり、更に水酸基を含む場合もある。Yは-(CH2)a-CH=CH-(CH2)a-又は-(CH2)a-(但しa,aは0~5の整数であり、a+aが5以下である)を表す。Zは-CO-又は-SO2-を表す。Rは-CH2OH、-CO2H、-CH2OCH2CO2H又は-CH2OSO3H基を表す。R0は-OH、-NH2又は-NHAc基を表す。]で示される化合物又は薬学的に許容し得る塩。【選択図】なし
